{"id":22626,"date":"2012-06-13T10:50:39","date_gmt":"2012-06-13T14:50:39","guid":{"rendered":"http:\/\/www.bahamasb2b.com\/news\/?p=22626"},"modified":"2012-06-13T11:02:02","modified_gmt":"2012-06-13T15:02:02","slug":"new-insights-into-jett-travoltas-seizure","status":"publish","type":"post","link":"https:\/\/www.bahamasb2b.com\/news\/2012\/06\/new-insights-into-jett-travoltas-seizure","title":{"rendered":"New Insights Into Jett Travolta\u2019s Seizure"},"content":{"rendered":"<figure id=\"attachment_22627\" aria-describedby=\"caption-attachment-22627\" style=\"width: 200px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-22627\" title=\"travolta-family\" src=\"https:\/\/www.bahamasb2b.com\/news\/wp-content\/uploads\/2012\/06\/travolta-family.jpg\" alt=\"\" width=\"200\" height=\"150\" srcset=\"https:\/\/www.bahamasb2b.com\/news\/wp-content\/uploads\/2012\/06\/travolta-family.jpg 200w, https:\/\/www.bahamasb2b.com\/news\/wp-content\/uploads\/2012\/06\/travolta-family-150x112.jpg 150w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><figcaption id=\"caption-attachment-22627\" class=\"wp-caption-text\">John Travolta and family, including son, Jett<\/figcaption><\/figure>\n<p>US patent 8,197,858 issued on June 12, 2012 discloses a previously unknown pathogenesis underlying seizures \/ epilepsy and migraines and provides novel treatment options for the 50 million seizure patients and 300 million migraine sufferers worldwide.<\/p>\n<p>&#8220;We scientifically validated that triggers such as drops in estrogen or testosterone or increases in prostaglandin or Vitamin D synthesis all boost release of calcium ions from bone.\u00a0 We also validated that boosting extracellular calcium ion levels boosts seizure and migraine risk by 1) depolarizing nerve membranes, 2) increasing calcium channel mediated neurotransmitter release and 3) boosting muscle contractility,&#8221;\u00a0 according to Mark Zamoyski,\u00a0 NexGen Biomedical, Inc.&#8217;s founder and the patent holder.<\/p>\n<p>&#8220;Why 50 million people worldwide have low seizures thresholds is not clear, however, the new pathogenesis provides an insight into factors that would increase their risk of having a seizure,&#8221;\u00a0 continued Mark Zamoyski.<\/p>\n<p>&#8220;We can begin to understand the perfect storm of risk factors that possibly contributed to 16 year old Jett Travolta&#8217;s uncontrollable seizure while on a vacation in the Bahamas.\u00a0 Puberty brings nighttime testosterone surges, followed by daytime drops, which boost calcium ion release from bone.\u00a0\u00a0 Sun exposure can boost Vitamin D synthesis to 25 times the RDA and sunburn boosts prostaglandin synthesis, both of which boost release of calcium from bone and hence boost seizure risk.\u00a0 And those are just some of the risk factors on the list.&#8221;<\/p>\n<p>&#8220;Previously unexplained migraine observations could now also be explained. As an example, one study found 45% of women with menstrual migraines had magnesium deficiency.\u00a0 The new pathogenesis explanation:\u00a0 It is known that estrogen levels drop precipitously at the start of menstruation.\u00a0 That in turn would result in a boost in extracellular calcium levels.\u00a0\u00a0 Magnesium is a physiological calcium channel blocker, which would attenuate the calcium channel mediated neurotransmitter release.&#8221;<\/p>\n<p>&#8220;Basically, the science indicates that anything that boosts release of calcium ions from bone boosts seizure and migraine risk and conversely anything that reduces release of calcium ions from bone reduces seizure and migraine risk.\u00a0 Fortunately, there are existing bone homeostasis drugs that could be easily repurposed to reduce seizure and migraine risk,&#8221;\u00a0 Mark Zamoyski summarized.<\/p>\n<p>More comprehensive data supporting the pathogenesis, and a list of things that increase or decrease release of calcium ions from bone, is provided at www.nexgen.biz.<\/p>\n<p>SOURCE NexGen Biomedical, Inc.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NexGen Biomedical, Inc. has new insights into the causes of seizures, including possible explanations of John Travolta&#8217;s 16-year-old son&#8217;s seizure-related death in the Bahamas.<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"facebook_10223285771444175_51037792744":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[18],"tags":[46,19,130],"class_list":["post-22626","post","type-post","status-publish","format-standard","hentry","category-lifestyle","tag-celebrities","tag-health","tag-medical"],"_links":{"self":[{"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/posts\/22626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/comments?post=22626"}],"version-history":[{"count":0,"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/posts\/22626\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/media?parent=22626"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/categories?post=22626"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bahamasb2b.com\/news\/wp-json\/wp\/v2\/tags?post=22626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}